Iowa State University · Microbiology & ImmunologyLupus Immune Regulation Group
Xue Han · Ames, Iowa
Research Focus
Dr. Xue Han's lab at Ohio State University focuses on understanding how the immune system is regulated in lupus, an autoimmune disease. The lab is investigating a specific protein called PD-1H that plays a crucial role in controlling immune responses in tissues affected by lupus. By studying how PD-1H functions, the lab aims to develop new therapies that can better manage lupus and improve patients' health.
lupusimmune regulationPD-1Hautoimmunitytherapeutic strategies
Research Aims
5AIM 01Investigate the role of PD-1H in regulating immune responses in lupus tissues.
AIM 02Map the distribution of PD-1H in kidney and skin biopsies from lupus patients.
AIM 03Evaluate the effects of PD-1H immune checkpoint activators in lupus models.
AIM 04Develop therapeutic strategies targeting PD-1H to modulate autoimmune pathogenesis.
AIM 05Understand how PD-1H interacts with signaling pathways in T cells.
Skills the Lab Values
immunofluorescencemouse modelsco-immunoprecipitationmultiplex imagingphosphoproteomics