Duke University · NeuroscienceIntegrated Stress Response Lab
Nicole Calakos · Durham, North Carolina
Research Focus
Dr. Nicole Calakos's lab at Duke University studies how a specific biochemical pathway influences the brain's ability to adapt and learn. They focus on how the Integrated Stress Response (ISR) affects the functioning of certain neurons involved in behaviors and memory. By understanding these mechanisms, the lab aims to identify potential new therapies for conditions related to memory and neurological disorders.
protein synthesissynaptic plasticityneurotransmissionneuromodulationIntegrated Stress Responselearningmemorycholinergic neuronscognitive functionneurodegenerative diseases
Research Aims
3AIM 01Investigate how the Integrated Stress Response affects synaptic plasticity and behavior.
AIM 02Explore the molecular mechanisms involved in dopamine signaling in cholinergic neurons.
AIM 03Develop new ISR reporters for high-resolution monitoring of protein synthesis during synaptic plasticity.
Skills the Lab Values
PCRcell culturemouse modelsviral vector designimmunohistochemistryWestern blotquantitative PCRbehavioural assaysoptogeneticsneuron imaging
Output against the department
Publications90bottom 29% of dept.475th of 671
this lab
most publishedleast published
Citations7.4ktop 50% of dept.337th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.