The University of Texas Medical Branch at Galveston · NeuroscienceOberhauser Muscle Lab
Andres F. Oberhauser · Galveston, Texas
Research Focus
Dr. Andres F. Oberhauser's lab studies how aging affects muscle proteins, particularly focusing on myosin and its chaperone UNC-45. As people age, they can lose muscle mass and strength, a condition known as sarcopenia, which impacts their quality of life. His research aims to understand the molecular changes to myosin and UNC-45 that contribute to sarcopenia using advanced techniques in both lab and animal models.
muscle agingsarcopeniamyosinUNC-45post-translational modificationsC. eleganschaperone proteinsprotein stabilitybiophysical assaysdrug design
Research Aims
5AIM 01Investigate how age-related modifications of UNC-45 affect its chaperone function.
AIM 02Determine the impact of aging on the stability and activity of myosin.
AIM 03Explore how preventing specific protein modifications can delay sarcopenia in aging models.
AIM 04Utilize C. elegans to uncover fundamental mechanisms of muscle aging.
AIM 05Establish new therapeutic strategies targeting muscle protein stabilization.
Skills the Lab Values
biochemical assaysin vivo techniquesC. elegans geneticsprotein purificationphosphorylation analysisWestern blottingfluorescence microscopydata analysis in biophysicsmutant generation
Output against the department
Publications123bottom 43% of dept.381st of 671
this lab
most publishedleast published
Citations11ktop 37% of dept.245th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.