MUSMedical University of South Carolina · Biology
Colorectal Cancer Immunology Lab
Silvia Guglietta · Charleston, South Carolina
Research Focus
Dr. Silvia Guglietta's lab focuses on understanding the role of the complement C3a receptor in the development of colorectal cancer (CRC) and its effects on the intestinal barrier and the microbiome. By exploring the communication between immune cells and epithelial cells in the intestines, her research aims to uncover how inflammation contributes to CRC initiation and progression. This research holds promise for improving strategies for CRC prevention and treatment through a better understanding of immune system interactions.
colorectal cancerC3a receptorintestinal barriermicrobiomeinflammationimmune response
Research Aims
3AIM 01Investigate how loss of C3aR affects the epithelial component of the intestinal barrier.
AIM 02Study the contribution of C3aR on immune and non-immune cell types to CRC development.
AIM 03Assess C3aR status in human pre-invasive lesions and CRC.
Skills the Lab Values
mouse modelsmass cytometrysingle-cell analysisbioinformaticsbone marrow chimeracell culturemolecular biology techniquesdata miningchromatography
Output against the department
Publications105bottom 36% of dept.656th of 1,033
this lab
most publishedleast published
Citations4.4kbottom 33% of dept.687th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.