University of California-Los Angeles · NeuroscienceAging and Neurodegeneration Lab
Hong-Wei Dong · Los Angeles, California
Research Focus
The Dong lab at UCLA focuses on understanding how aging and Alzheimer's disease affect the brain at a cellular level. Using advanced techniques like single-cell RNA sequencing and 3D mapping, we study specific types of brain cells in mice to uncover the changes that occur as these animals age or develop Alzheimer's. Our research aims to create detailed brain atlases that can help scientists worldwide study neurodegenerative diseases more effectively.
Alzheimer's Diseaseconnectivitycell-type mappingagingmolecular profiling
Research Aims
5AIM 01Map cellular resolution features of neurons in Alzheimer's patients
AIM 02Characterize age-dependent changes in brain cell types
AIM 03Develop 3D brain atlases for aging and Alzheimer’s research
AIM 04Quantify axonal connectivity changes in mice
AIM 05Establish a web-based resource for neuroscience data visualization.
Skills the Lab Values
single-nucleus RNA sequencing3D imagingcell culturemorphological analysisCRISPR techniques
Output against the department
Publications101bottom 34% of dept.443rd of 671
this lab
most publishedleast published
Citations20ktop 22% of dept.146th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.