WMCWeill Medical College of Cornell University · Biomedical Engineering
Santambrogio Immunology Lab
Laura Santambrogio · New York, New York
Research Focus
Dr. Laura Santambrogio's lab focuses on understanding a newly discovered compound derived from tryptophan metabolism called 3HKA, which exhibits anti-inflammatory properties. They study how this compound interacts with immune cells, proposes its potential therapeutic applications for autoimmune diseases like psoriasis and lupus, and develop similar compounds to enhance immunomodulation. The lab integrates techniques from biochemistry and immunology to explore how metabolism influences immune system behavior.
tryptophan metabolismimmunologyanti-inflammatory agentsautoimmune diseaseskynureninesT cell activationbiogenic aminessignal transductionimmunomodulation
Research Aims
4AIM 01Characterize the enzyme responsible for the production of 3HKA.
AIM 02Identify the receptor target of 3HKA and analyze its expression profile.
AIM 03Examine the signal transduction pathway activated by 3HKA.
AIM 04Develop and screen analogs of 3HKA for their anti-inflammatory properties.
Skills the Lab Values
biochemical assayscell cultureimmunophenotypingCRISPR/Cas9animal modelsflow cytometrymass spectrometryprotein biochemistryphosphoproteomics
Output against the department
Publications220top 48% of dept.285th of 595
this lab
most publishedleast published
Citations27ktop 12% of dept.69th of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.