Yale University · BiochemistryProtein Interaction and Modification Lab
Farren J. Isaacs · New Haven, Connecticut
Research Focus
Farren J. Isaacs' lab at Yale University focuses on understanding how proteins interact with each other and how their functions are modified by chemical changes called post-translational modifications (PTMs). By engineering bacteria to produce proteins with specific modifications, the lab aims to uncover the role of these modifications in crucial cellular processes and disease states. This pioneering work could lead to the development of new therapeutic strategies targeting diseases linked to protein interactions.
post-translational modificationsprotein-protein interactionssynthetic biologygenome engineeringdrug discoveryrecoded organismsE. coli
Research Aims
3AIM 01Utilize a recoded organism to encode specific post-translational modifications in proteins.
AIM 02Develop a method to identify protein binders that interact based on their PTMs.
AIM 03Engineer small protein binders to target disease-relevant phosphorylated proteins.
Skills the Lab Values
protein engineeringsynthetic biology techniquesE. coli culturehigh-throughput screeningmolecular cloningCRISPRbiochemical assaysprotein purificationdata analysis in genomicsbioinformatics
Output against the department
Publications95bottom 23% of dept.311th of 402
this lab
most publishedleast published
Citations12ktop 42% of dept.169th of 402
this lab
most citedleast cited
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