Johns Hopkins University · BiologySympathetic Neuron-Glia Interaction Lab
Rejji Kuruvilla · Baltimore, Maryland
Research Focus
Dr. Rejji Kuruvilla's lab at Johns Hopkins University focuses on the interactions between sympathetic neurons and satellite glial cells, which play crucial roles in the sympathetic nervous system. The lab investigates how these glial cells, often overlooked, help regulate neuronal activity and contribute to overall body physiology. By exploring the development and communication mechanisms of these cell types, the research aims to uncover insights that could lead to new therapies for disorders such as chronic heart failure and hypertension.
sympathetic nervous systemsatellite glianeuron-glia interactionschronic heart failurehypertensioninsulin resistanceneurotrophinscell communicationneural circuitsdevelopmental biology
Research Aims
5AIM 01Explore how sympathetic neuron-satellite glia units are established during development.
AIM 02Investigate the molecular mechanisms behind neuron-glia communication.
AIM 03Assess the impact of satellite glial cells on neuronal connectivity.
AIM 04Examine how perturbations in neuron-glia interactions affect sympathetic function.
AIM 05Identify potential therapeutic targets for disorders linked to sympathetic dysfunction.
Skills the Lab Values
mouse modelscell cultureco-culture techniquesbiochemistryimaginggenetic manipulationWestern blotPCRhistologyin vivo imaging
Output against the department
Publications92bottom 31% of dept.715th of 1,033
this lab
most publishedleast published
Citations4.5kbottom 35% of dept.673rd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.