University of Pennsylvania · Microbiology & ImmunologyHIV Persistence Research Lab
Michael R Betts · Philadelphia, Pennsylvania
Research Focus
Dr. Michael Betts' lab focuses on understanding the mechanisms that allow HIV to persist in infected individuals, which is crucial for developing effective cure strategies. They utilize advanced techniques to analyze the immune response and the characteristics of the HIV reservoir, with the aim of enhancing treatments for people living with HIV. The research seeks to identify potential therapeutic targets to improve immune responses and reduce the viral reservoir in patients.
HIVviral reservoirimmune responsebroadly neutralizing antibodiescell death resistance
Research Aims
4AIM 01Investigate cell death resistance mechanisms in the HIV reservoir.
AIM 02Characterize the effects of broadly neutralizing antibodies on immune responses at ART initiation.
AIM 03Define how the HIV reservoir changes over time under treatment.
AIM 04Analyze the immune features associated with successful viral control after therapy.
Skills the Lab Values
single cell RNA sequencingATAC-seqepigenetic profilingcell culturetranscriptome analysis
Output against the department
Publications297top 17% of dept.82nd of 486
this lab
most publishedleast published
Citations32ktop 9% of dept.46th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.