University of Rochester · BiologyAging and Genomic Stability Lab
Vera Gorbunova · Rochester, New York
Research Focus
The research lab led by Dr. Vera Gorbunova at the University of Rochester focuses on understanding the aging process and strategies to maintain genomic stability in cells. They investigate how certain genes, particularly Sirtuin 6, influence lifespan and epigenetic rejuvenation, and use comparative genomics to explore longevity mechanisms in various animal species. The goal is to apply these insights to prevent age-related diseases such as Alzheimer's.
longevitygenome stabilityepigeneticsSirtuin 6Alzheimer's diseasecomparative genomicsDNA repaircell rejuvenationaging mechanisms
Research Aims
4AIM 01Investigate the role of Sirtuin 6 and its intrinsically disordered regions in aging.
AIM 02Characterize RNA interactions and biomolecular condensates formed by Sirtuin 6.
AIM 03Examine the effects of Sirtuin 6 on DNA repair and telomere maintenance.
AIM 04Identify mechanisms that contribute to longevity in various mammalian species.
Skills the Lab Values
CRISPRRNA sequencingsuper-resolution microscopycell culturemouse modelsbiomolecular condensate analysisbioinformaticsgene expression analysisDNA repair assays
Output against the department
Publications454top 9% of dept.97th of 1,033
this lab
most publishedleast published
Citations26ktop 14% of dept.146th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.