University of California-San Diego · Biomedical EngineeringAdvanced Cancer Therapeutics Lab
Sunil J Advani · La Jolla, California
Research Focus
Dr. Sunil J Advani's lab focuses on improving treatments for locally advanced cancers through innovative therapies that combine radiotherapy with targeted drug delivery. The lab utilizes antibody drug conjugates (ADCs) to specifically deliver radiosensitizers to cancer cells, enhancing tumor control while minimizing damage to normal tissues. Through examining the immune response in the tumor microenvironment, the lab aims to develop molecularly guided precision therapies that are more effective and less toxic than conventional treatments.
antibody-drug conjugatesradio-chemo-immunotherapytumor targetingradiosensitizationimmune checkpoint inhibitioncancer therapeuticstumor microenvironmentCD8 T cellsDNA damage repairprecision medicine
Research Aims
3AIM 01Evaluate the impact of auristatins on the tumor immune microenvironment and tumor control.
AIM 02Investigate how immunotherapies can enhance the effectiveness of radiosensitizing agents.
AIM 03Test the efficacy of first-in-class ADCs with ATM inhibitor warheads for selective tumor radiosensitization.
Skills the Lab Values
cell cultureanimal modelsantibody-drug conjugationimmunotherapy techniquesflow cytometryPCRmolecular cloningWestern blottingradiation exposure techniquesdata analysis in cancer research
Output against the department
Publications149bottom 32% of dept.402nd of 595
this lab
most publishedleast published
Citations2.3kbottom 17% of dept.496th of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.