Duke University · Microbiology & ImmunologyLung Immune Response Laboratory
Mari L. Shinohara · Durham, North Carolina
Research Focus
Dr. Mari Shinohara's lab at Duke University focuses on understanding how alveolar macrophages, a type of immune cell in the lungs, respond to fungal infections. They investigate how these macrophages can have both protective and harmful responses during infections, and aim to uncover the molecular mechanisms that lead to their diverse behavior. This research is essential for developing better treatments for patients suffering from pulmonary fungal infections.
alveolar macrophagesfungal infectionsimmune responseinflammationepigeneticssingle-cell RNA sequencingflow cytometryimmune heterogeneitytherapeutic interventions
Research Aims
5AIM 01Elucidate the biological functions of alveolar macrophages during pulmonary fungal infections.
AIM 02Identify functionally distinct subpopulations of alveolar macrophages.
AIM 03Investigate the transcriptional and epigenetic regulations of macrophage responses to infections.
AIM 04Understand how distinct macrophage subpopulations contribute to fungal clearance and lung protection.
AIM 05Explore the signaling pathways involved in the immune responses of macrophages to fungal pathogens.
Skills the Lab Values
flow cytometrysingle-cell RNA sequencinggene expression profilingin vivo modelsmulti-color flow cytometryepigenetic analysismouse handlingcell culturechromatin studies
Output against the department
Publications124bottom 47% of dept.257th of 486
this lab
most publishedleast published
Citations18ktop 21% of dept.101st of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.