WMCWeill Medical College of Cornell University · Pharmacology
Epitranscriptomics and Gene Regulation Lab
Samie R Jaffrey · New York, New York
Research Focus
Dr. Samie Jaffrey's lab at Weill Medical College focuses on understanding how chemical modifications in RNA molecules influence gene expression and cellular behavior, particularly in the context of cancer and neuronal function. The lab employs innovative techniques to map and analyze these modifications, contributing to the emerging field of epitranscriptomics. Through interdisciplinary collaboration and advanced methodologies, the lab seeks to unravel the complex regulatory mechanisms governing RNA and its impact on health and disease.
epitranscriptomicsRNA modificationscancer biologymRNA regulationneuronal function
Research Aims
5AIM 01Investigate how nucleotide modifications in RNA regulate gene expression in cancer and neurons.
AIM 02Develop new technologies for the mapping and quantification of RNA modifications.
AIM 03Explore the effects of m6A modifications on cellular fate and differentiation.
AIM 04Determine the role of specific RNA-binding proteins in regulating post-transcriptional gene expression.
AIM 05Evaluate the therapeutic potential of targeting RNA modifications in cancer treatment.
Skills the Lab Values
RNA sequencingCRISPRmass spectrometrycell culturemolecular cloningbioinformaticsfluorescence microscopyRNA extractionconditional knockout mouse modelsgene expression profiling
Output against the department
Publications278top 28% of dept.129th of 462
this lab
most publishedleast published
Citations45ktop 5% of dept.25th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.