University of California-San Diego · PharmacologyTrejo Lab
Joann Trejo · La Jolla, California
Research Focus
Dr. Joann Trejo's lab at UC San Diego focuses on understanding how G protein-coupled receptors (GPCRs) signal within cells and contribute to various diseases, including vascular inflammation and cancer. The lab explores innovative mechanisms that regulate GPCRs and their signaling pathways, particularly in the context of endothelial dysfunction. This research aims to improve therapeutic options for diseases related to endothelial injury by targeting specific GPCR signaling mechanisms.
G protein-coupled receptorsendothelial dysfunctionvascular inflammationubiquitinationcell signalingtherapeutic developmentprotease-activated receptor-1cancer progressionanti-apoptotic signalingGPCR trafficking
Research Aims
5AIM 01Investigate the regulatory mechanisms of GPCR signaling from endosomes.
AIM 02Identify how deubiquitinases influence GPCR-stimulated p38 signaling in vascular inflammation.
AIM 03Define the mechanisms by which activated protein C promotes endothelial barrier protection via PAR1.
AIM 04Explore how distinct GRK5 functions shape biased signaling in GPCRs.
AIM 05Elucidate the role of Cav1 phosphorylation in cytoprotection mediated by APC/PAR1.
Skills the Lab Values
cell cultureG protein-coupled receptor signalingCRISPR/Cas9Western blottingimmunofluorescence microscopyendothelial cell assaysMAPK signaling analysisprotein ubiquitinationgene expression analysisco-immunoprecipitation
Output against the department
Publications190top 47% of dept.215th of 462
this lab
most publishedleast published
Citations8.2ktop 45% of dept.210th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.