Southern Methodist University · ChemistryMycobacterial Antibiotic Development Lab
John D Buynak · Dallas, Texas
Research Focus
Dr. John D Buynak's lab focuses on developing new antibiotics to fight mycobacterial infections, particularly those caused by Mycobacterium tuberculosis and non-tuberculous mycobacteria. The lab aims to create effective carbapenem antibiotics that can overcome the resistance commonly displayed by these pathogens. By modifying the chemical structure of existing antibiotics, they seek to enhance their potency and make them suitable for oral administration, which is crucial for improving treatment outcomes.
antibioticsmycobacterial infectionscarbapenemsdrug resistancesynthesis chemistryantimycobacterial agentsdrug designstructural biologybiochemical analysis
Research Aims
5AIM 01Design new carbapenem antibiotics with improved activity against mycobacterial infections.
AIM 02Synthesize atypical carbapenems with unique structural modifications.
AIM 03Evaluate the potency of new compounds against resistant strains of mycobacteria.
AIM 04Develop orally bioavailable formulations of effective antimycobacterial agents.
AIM 05Assess the stability of new antibiotics against hydrolysis by beta-lactamases.
Skills the Lab Values
organic synthesismicrobiology techniquesin vitro testingin vivo pharmacokineticsbiochemical assaysantibiotic susceptibility testingchemical modificationstructure-activity relationship analysiscrystallography techniques
Output against the department
Publications140bottom 33% of dept.144th of 216
this lab
most publishedleast published
Citations2.6kbottom 18% of dept.177th of 216
this lab
most citedleast cited
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