Preeclampsia Research Lab
Jessica L. Faulkner · Augusta, Georgia
Augusta University · Physiology
Research focus
Dr. Jessica L. Faulkner's lab at Augusta University focuses on understanding preeclampsia, a serious pregnancy complication marked by high blood pressure. The research examines how the hormone leptin, which is found in elevated levels in preeclampsia patients, affects maternal and fetal health by causing cardiovascular issues. By using mouse models, the lab investigates the mechanisms underlying leptin's role in this condition, with the aim of developing better treatments.
preeclampsialeptincardiovascular diseaseplacental dysfunctionhypertensionmaternal healthfetal growth restrictionendothelial dysfunctionadipokines
Research aims
4AIM 01Investigate how placental ischemia increases leptin levels through sFlt-1 in preeclampsia.
AIM 02Examine the role of endothelial leptin receptors in mediating hypertension and fetal growth restriction.
AIM 03Determine the impact of endothelin-1 in leptin-induced endothelial dysfunction in pregnant mice.
AIM 04Evaluate the potential of targeting leptin regulatory pathways for therapeutic purposes in preeclampsia.
Skills the lab values
mouse modelsendothelial cell culturehormone assaysvascular function testsWestern blottingPCRblood pressure monitoringimmunohistochemistryCRISPR
Output against the department
126publicationsbottom 39% of the department174th of 286
most publishedleast published
3.0kcitationsbottom 24% of the department217th of 286
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. Position on each rail is this lab's rank, not its distance from the top: a department runs from one paper to tens of thousands, so rank is the only comparison that stays readable across it.