Indiana University-Purdue University-Indianapolis · BiologyTDP-43 Neurodegeneration Research Unit
Kathy L Newell · Indianapolis, Indiana
Research Focus
Dr. Kathy L Newell's research lab at Indiana University Indianapolis focuses on understanding the role of TDP-43 protein in various neurodegenerative diseases, such as Frontotemporal Lobar Degeneration (FTLD) and Amyotrophic Lateral Sclerosis (ALS). By investigating the molecular changes and mislocalization of TDP-43, her team aims to uncover the mechanisms behind different clinical presentations of these diseases. Their innovative approach combines advanced imaging and molecular techniques to study the structure and modifications of TDP-43, which could lead to new diagnostic and therapeutic strategies.
TDP-43neurodegenerative diseasesFrontotemporal Degenerationmolecular geneticsprotein aggregationneuroinflammationpost-translational modificationsimmunohistochemistrycryogenic microscopydiagnostic biomarkers
Research Aims
3AIM 01Investigate the spatial distribution of TDP-43 inclusions in neuronal and glial populations.
AIM 02Identify novel post-translational modifications associated with misfolded TDP-43.
AIM 03Characterize the structure of TDP-43 filaments using cutting-edge cryogenic electron microscopy.
Skills the Lab Values
immunohistochemistrycryogenic electron microscopy (cryo-EM)RT-QuIC assayquantitative digital image analysismolecular characterization of proteinsfluorescent multiplex immunohistochemistryproteomics techniquesDNA-binding protein analysisdigital spatial profilingdata analysis in neuropathology
Output against the department
Publications159top 42% of dept.435th of 1,033
this lab
most publishedleast published
Citations8.7ktop 44% of dept.450th of 1,033
this lab
most citedleast cited
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