University of Chicago · Microbiology & ImmunologyGolovkina Immunology Lab
Tatyana V Golovkina · Chicago, Illinois
Research Focus
Dr. Tatyana Golovkina's lab at the University of Chicago investigates how certain retroviruses interact with the immune system and the microbiota to influence viral infections and cancer development. They focus on understanding the regulation of immune responses by a special molecule called H2-O and exploring how gut bacteria can promote or impede the progression of leukemia induced by viruses. Their research aims to uncover new mechanisms that could improve vaccinations and therapeutic strategies against viral infections and cancer.
retrovirusesimmune regulationMHC IIantibody responsemicrobiotatumorigenesisleukemiaimmune suppression
Research Aims
5AIM 01Examine how H2-O modulates MHCII antigen presentation to enhance immune responses.
AIM 02Identify genetic factors in the mouse model that contribute to neutralizing antibody production.
AIM 03Investigate the role of gut bacteria in influencing leukemia development via immune suppression.
AIM 04Characterize how microbiota-induced immune regulators affect cancer progression.
AIM 05Determine the mechanisms by which negative regulators of immunity are upregulated in response to gut microbes.
Skills the Lab Values
molecular cloningantibody generationcell cultureanimal modelsbiochemical assaysflow cytometrygene editingbioinformaticsimmunological assays
Output against the department
Publications67bottom 19% of dept.394th of 486
this lab
most publishedleast published
Citations3.2kbottom 23% of dept.374th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.