Iowa State University · PhysiologySingh Cardiac Lab
Harpreet Singh · Ames, Iowa
Research Focus
Dr. Harpreet Singh's lab at Ohio State University focuses on understanding the roles of specific potassium channels in heart and cell function, particularly in relation to exosomes and mitochondria. The team investigates how these channels can affect heart health, including preventing damage during conditions like ischemia. Their research may lead to new therapies for heart disease by exploring the potential of exosomal channels in drug delivery and cardiac protection.
exosomespotassium channelscardiac physiologymitochondrial functioncardioprotectionischemia-reperfusion injurygene expressionsignal transductionelectrophysiology
Research Aims
5AIM 01Establish the molecular identity and properties of exosomal BK channels.
AIM 02Determine the physiological role of BK channels in exosomes.
AIM 03Elucidate the mechanisms by which exosomal BK channels provide cardioprotection.
AIM 04Investigate the signaling pathways influenced by mitoBK in cardiac hypertrophy.
AIM 05Explore the regulatory mechanisms involving mitochondrial function and cardiac health.
Skills the Lab Values
exosome isolationpatch-clamp electrophysiologymouse genetic modelscell culture techniquesmolecular biology methodsdata analysis using PythonWestern blottingimmunofluorescence microscopyflow cytometry
Output against the department
Publications98bottom 28% of dept.207th of 286
this lab
most publishedleast published
Citations508bottom 1% of dept.282nd of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.