Yale University · GeneticsGiraldez Genomics Lab
Antonio J Giraldez · New Haven, Connecticut
Research Focus
Dr. Antonio J. Giraldez's lab at Yale University focuses on understanding how the structure of the genome influences gene expression during early development, particularly in zebrafish. They investigate the mechanisms that allow gene regulatory elements, like enhancers and promoters, to communicate effectively, which is crucial for proper embryonic development. The lab employs innovative techniques such as expansion microscopy to visualize chromatin organization and to decode genetic variations that affect gene function.
chromatin organizationgene regulationembryonic developmentexpansion microscopygenomic variantsenhancer-promoter interaction3D genome architectureUTR sequence variation
Research Aims
4AIM 01Investigate how genomic structures and histone modifications regulate gene expression during early development.
AIM 02Describe the interactions between enhancers and promoters at a genome-wide scale.
AIM 03Develop new methods for high-resolution imaging of chromatin structure.
AIM 04Understand the role of untranslated regions in gene regulation and protein output during embryogenesis.
Skills the Lab Values
expansion microscopychromatin immunoprecipitation (ChIP-seq)gene expression analysisRNA sequencingfluorescence in situ hybridization (FISH)cell culturezebrafish modelshigh-throughput sequencingbioinformatics
Output against the department
Publications107bottom 32% of dept.175th of 259
this lab
most publishedleast published
Citations15ktop 37% of dept.95th of 259
this lab
most citedleast cited
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