University of Kentucky · PhysiologyRNA Modifications and Muscle Health Lab
Yuan Wen · Lexington, Kentucky
Research Focus
Dr. Yuan Wen's lab at the University of Kentucky focuses on understanding how RNA modifications affect muscle function as we age. By using advanced sequencing technology and artificial intelligence, the lab investigates how changes in RNA influence protein production in different muscle fibers. Their work aims to uncover new strategies to mitigate age-related muscle loss and improve overall muscle health in older adults.
RNA modificationsmuscle agingartificial intelligencenanopore sequencingprotein synthesisgene expressionmuscle physiologyage-related muscle lossRNA-based therapeutics
Research Aims
5AIM 01Develop methods to detect RNA modifications in aging muscle
AIM 02Examine modification patterns in fast- and slow-twitch muscle fibers
AIM 03Determine the impact of RNA modifications on protein synthesis
AIM 04Establish new paradigms for studying RNA in aging tissues
AIM 05Identify potential therapeutic targets for muscle loss.
Skills the Lab Values
Nanopore sequencingDeep learningRNA biologyExperimental designData analysisCell cultureMolecular biology techniquesBioinformaticsMachine learning applicationsProtein analysis
Output against the department
Publications100bottom 29% of dept.203rd of 286
this lab
most publishedleast published
Citations2.9kbottom 22% of dept.222nd of 286
this lab
most citedleast cited
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