Icahn School of Medicine at Mount Sinai · PharmacologyOpioid Innovations Lab
Marta Filizola · New York, New York
Research Focus
Marta Filizola's research lab focuses on developing safer opioids to combat the opioid crisis by better understanding how different drugs interact with opioid receptors. By combining advanced computational models and experimental imaging techniques, the lab seeks to discover pain-relieving medications that have fewer side effects than traditional opioids. This research is crucial for creating new therapies that can help patients manage pain effectively while minimizing the risks of addiction and overdose.
opioid receptorsanalgesicscomputational modelingsingle-molecule imagingdrug safetyBayesian inferencemachine learningopioid use disorderlow-efficacy agonists
Research Aims
5AIM 01Develop safer opioid analgesics that minimize side effects.
AIM 02Understand the mechanisms of low-efficacy opioid receptor agonists.
AIM 03Integrate computational and experimental data to study opioid receptor dynamics.
AIM 04Utilize machine learning to predict the efficacy of new opioid compounds.
AIM 05Validate predictions experimentally to inform drug development.
Skills the Lab Values
molecular dynamics simulationsBayesian modelingsingle-molecule imagingcryoelectron microscopybioluminescence assaysdata integrationprotein dynamics analysisstatistical modelingpharmaceutical preparation
Output against the department
Publications269top 29% of dept.135th of 462
this lab
most publishedleast published
Citations9.5ktop 40% of dept.186th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.