New York University · BiochemistryCastel Tumorigenesis Lab
Pau Castel · New York, New York
Research Focus
Dr. Pau Castel's lab focuses on understanding rare neurogenetic disorders and their associated molecular mechanisms, particularly Schwannomatosis, which involves the growth of nerve tumors. The research aims to identify how genetic mutations affect Schwann cells and contribute to tumor formation, and to explore potential treatments. The lab also studies the roles of non-classical RAS oncoproteins in cancer, looking for new ways to target these molecules for better cancer therapies.
SchwannomatosisRAS OncoproteinsTumorigenesisPharmacological TreatmentsGenetic Mutations
Research Aims
5AIM 01Develop cellular models to study LZTR1-related Schwannomatosis.
AIM 02Investigate the genetic interaction between LZTR1 and NF2 in Schwann cells.
AIM 03Explore novel therapeutic interventions for targeting Schwannomatosis.
AIM 04Analyze the regulation of non-classical RAS oncoproteins in cancer.
AIM 05Create mouse models to study RIT1-driven tumors.
Skills the Lab Values
Cell CultureMolecular CloningMouse ModelsBiochemical AssaysRNA SequencingWestern BlottingFlow CytometryGenetic EngineeringDrug Screening
Output against the department
Publications185top 46% of dept.183rd of 402
this lab
most publishedleast published
Citations3.8kbottom 20% of dept.321st of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.