University of North Carolina at Asheville · ChemistryWolfe Antibiotics Lab
Amanda Lynn Wolfe · Asheville, North Carolina
Research Focus
Dr. Amanda Lynn Wolfe's lab focuses on developing new antibiotics to combat multidrug-resistant infections caused by tough Gram-negative bacteria, like Pseudomonas aeruginosa and Acinetobacter baumannii. The lab is researching novel enzymes involved in bacteria's energy production, aiming to find new ways to deliver antibiotics effectively while overcoming bacterial resistance. Their work is critical in addressing the urgent need for new treatment options as current antibiotics become ineffective.
antibiotic resistanceGram-negative bacteriabacterial biofilmsoxidative phosphorylationdrug discoveryenzyme inhibitorsmultidrug resistant pathogensbiochemical methodsantibiotic delivery
Research Aims
5AIM 01Identify new antibiotic targets within the oxidative phosphorylation system of Gram-negative bacteria.
AIM 02Develop small molecule inhibitors that effectively penetrate bacterial membranes and biofilms.
AIM 03Optimize existing ATP synthase inhibitors for greater efficacy against resistant strains.
AIM 04Explore novel enzyme complexes for potential antibiotic development.
AIM 05Establish high-throughput methods to evaluate new antibiotic candidates.
Skills the Lab Values
microscopyhigh-throughput screeningin vitro assaysprotein purificationorganic synthesisspectroscopybiochemical analysiscell culturedata analysis
Output against the department
Publications4bottom 1% of dept.214th of 216
this lab
most publishedleast published
Citations0bottom 1% of dept.216th of 216
this lab
most citedleast cited
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