University of Kentucky · PharmacologyThe Detox Lab
Fang Zheng · Lexington, Kentucky
Research Focus
Dr. Fang Zheng's lab at the University of Kentucky focuses on developing new treatments for poisoning caused by the highly toxic pesticide aldicarb. The lab is working to create a bioscavenger enzyme that can effectively detoxify aldicarb faster than it can poison the acetylcholinesterase enzyme in the body. Their research aims to provide better medical countermeasures against potential threats from cholinergic agents used in chemical warfare.
AldicarbBioscavengerToxicityCholinergic WarfareEnzyme Engineering
Research Aims
5AIM 01Develop an engineered enzyme to detoxify aldicarb poisoning
AIM 02Evaluate a library of Fc-fused proteins for aldicarb hydrolysis
AIM 03Optimize catalytic activity of selected enzymes against aldicarb
AIM 04Assess the safety and efficacy of candidate enzymes in vivo
AIM 05Identify potential clinical candidates for aldicarb poisoning treatment.
Skills the Lab Values
Enzyme engineeringAnimal modelsIn vitro hydrolysisProtein purificationBiochemical assays
Output against the department
Publications363top 19% of dept.86th of 462
this lab
most publishedleast published
Citations9.5ktop 40% of dept.187th of 462
this lab
most citedleast cited
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