University of Texas Southwestern Medical Center · BiochemistryThe Amyloid Dynamics Lab
Kendra King Frederick · Dallas, Texas
Research Focus
Dr. Kendra King Frederick's lab focuses on understanding the structures and behaviors of amyloid proteins, particularly alpha-synuclein, which are linked to neurodegenerative diseases like Parkinson's and Lewy body dementia. The research combines advanced imaging techniques to examine how these proteins form and propagate within different cellular environments, aiding in the development of better diagnostic tools and therapies.
AmyloidAlpha-synucleinNeurodegenerative diseasesCellular environmentProtein aggregation
Research Aims
5AIM 01Investigate the conformations of alpha-synuclein inside cells.
AIM 02Examine how cellular environments influence amyloid propagation.
AIM 03Analyze amyloid structures from patient tissues.
AIM 04Compare in vitro and in vivo amyloid fibril formations.
AIM 05Advance our understanding of neurodegenerative disease mechanisms.
Skills the Lab Values
Cryo-electron tomographySolid-state NMR spectroscopyCell cultureBiosensor assaysIn vitro aggregation assays
Output against the department
Publications48bottom 7% of dept.375th of 402
this lab
most publishedleast published
Citations2.1kbottom 7% of dept.372nd of 402
this lab
most citedleast cited
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