Upstate Medical University · BiochemistrySystemic Amyloidosis Research Lab
Stewart N Loh · Syracuse, New York
Research Focus
Dr. Stewart Loh's lab at Upstate Medical University focuses on understanding systemic amyloidosis, a serious condition caused by misfolded proteins accumulating in various organs like the kidneys and heart. The lab uses innovative microfluidic devices that mimic kidney blood flow to study how shear stress affects protein misfolding and aggregation. The ultimate goal is to create early diagnostic tests using biosensors that can detect these protein aggregates in patients' blood and urine.
systemic amyloidosisprotein misfoldingmicrofluidic deviceskidney functionbiosensors
Research Aims
5AIM 01Investigate how laminar flow shear affects protein misfolding.
AIM 02Develop microfluidic devices to replicate kidney blood flow.
AIM 03Characterize misfolded proteins using advanced microscopy techniques.
AIM 04Create biosensors for early detection of systemic amyloidosis.
AIM 05Validate biosensor effectiveness with patient samples.
Skills the Lab Values
microfluidic device fabricationcryogenic electron microscopy (cryo-EM)fluorescence microscopybiophysical characterizationprotein aggregation assays
Output against the department
Publications131bottom 37% of dept.252nd of 402
this lab
most publishedleast published
Citations3.9kbottom 20% of dept.320th of 402
this lab
most citedleast cited
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