University of Michigan-Ann Arbor · Mathematics & StatisticsSomatic Mosaicism Research Unit
Ryan E Mills · Ann Arbor, Michigan
Research Focus
Ryan E Mills' lab at the University of Michigan focuses on understanding variations in the human genome, specifically somatic mosaicism, which refers to genetic differences within an individual’s tissues. By developing advanced molecular and computational tools, the lab aims to uncover overlooked mutations that occur in various tissues and may be linked to diseases like cancer. Their work is crucial for improving our understanding of how these genetic variations contribute to health and disease.
somatic mosaicismgenomic variationcancer geneticshigh-throughput sequencingcomputational biology
Research Aims
4AIM 01Develop innovative molecular assays for detecting somatic mosaicism.
AIM 02Optimize computational approaches for analyzing genomic data.
AIM 03Explore somatic variation across different human tissues.
AIM 04Enhance detection methods for low-frequency somatic mutations.
Skills the Lab Values
molecular assaysnanopore sequencingsingle cell sequencinggenome analysisbioinformatics
Output against the department
Publications190bottom 40% of dept.79th of 131
this lab
most publishedleast published
Citations41ktop 12% of dept.16th of 131
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.