UGUniversity of Georgia · Microbiology & Immunology
The Microbial Metabolism Lab
Jorge C Escalante · Athens, Georgia
Research Focus
Dr. Jorge C Escalante's lab at the University of Georgia focuses on understanding how prokaryotic cells, like bacteria, manage their metabolism to adapt to different environments, including during infections. The lab studies specific enzymes that modify other proteins and examines the complex process of making a large coenzyme essential for microbial life. They use advanced techniques to visualize these intricate molecular structures and aim to uncover new therapeutic targets for human diseases related to microbial infections.
prokaryotic metabolismenzyme modificationcoenzyme B12Salmonella pathogenesismolecular biology
Research Aims
5AIM 01Define the function of enzymes that modify regulatory proteins.
AIM 02Investigate the biosynthesis pathway of coenzyme B12.
AIM 03Use liposome methodologies to study enzyme complex assembly.
AIM 04Visualize molecular structures with microscopy.
AIM 05Explore the role of transcription factors in iron metabolism during Salmonella infections.
Skills the Lab Values
cell culturebiochemical assaysenzyme kineticsliposome methodologiesmicroscopy techniquesDNA/RNA manipulationbioinformatics analysisprotein expressionspectroscopyprotein purification