Virginia Commonwealth University · BiochemistryLiver Cancer and Sexual Health Lab
Christopher D Green · Richmond, Virginia
Research Focus
Dr. Christopher D. Green's research lab examines how sexual differences affect the development of liver cancer, specifically hepatocellular carcinoma (HCC). By using animal models that mimic human obesity-related liver disease, the lab explores the roles of specific enzymes, particularly sphingosine kinase 2, in these processes. The findings aim to improve understanding of liver cancer risk in men and women, potentially leading to personalized treatment options.
hepatocellular carcinomasexual dimorphismsphingosine kinase 2liver cancerobesityNASHsphingolipidstranslational research
Research Aims
4AIM 01Investigate the role of sphingosine kinase 2 in promoting hepatocellular carcinoma in male mice.
AIM 02Define the protective mechanisms of sphingosine kinase 2 against hepatocellular carcinoma in female mice.
AIM 03Examine the signaling pathways activated by sphingosine kinase 2 in liver cancer progression.
AIM 04Identify metabolic changes in the liver associated with sexual dimorphism in hepatocellular carcinoma.
Skills the Lab Values
animal modelsdiet-induced liver disease modelinghistological analysisgene expression profilingmetabolomicsbiochemical assayscell cultureWestern blottingmicroscopy
Output against the department
Publications69bottom 13% of dept.349th of 402
this lab
most publishedleast published
Citations2.7kbottom 13% of dept.350th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.