University of Pennsylvania · BiologyDeng Lab
Yanxiang Deng · Philadelphia, Pennsylvania
Research Focus
Dr. Yanxiang Deng's lab at the University of Pennsylvania focuses on studying the human hippocampus and its role in aging and Alzheimer's Disease. The lab is developing innovative technologies to analyze the complex cellular environments in brain tissue, aiming to uncover how different cell types contribute to memory impairment and disease progression. By combining multiple molecular profiling techniques, the lab hopes to identify potential new strategies for treatment and deepen our understanding of brain health.
Alzheimer's Diseasemulti-omicsepigeneticscellular profilinghippocampusagingneurobiologymemory impairmenttissue organization
Research Aims
5AIM 01Develop a technology for spatial co-profiling of epigenome, transcriptome, and proteins.
AIM 02Map cellular states in the human hippocampus to understand their role in Alzheimer's Disease.
AIM 03Identify molecular signatures associated with cell vulnerability and resilience.
AIM 04Explore therapeutic approaches that target identified cell types.
AIM 05Construct comprehensive maps that link tissue organization with gene regulatory networks.
Skills the Lab Values
spatial omicsepigenomic profilingRNA sequencingimmunohistochemistrycell culturedata visualizationimage analysisbioinformaticshistological techniques
Output against the department
Publications70bottom 19% of dept.834th of 1,033
this lab
most publishedleast published
Citations4.3kbottom 33% of dept.693rd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.