UTMThe University of Texas MD Anderson Cancer Center · Genetics
Guarnerio Oncology Lab
Jlenia Guarnerio · Houston, Texas
Research Focus
Dr. Jlenia Guarnerio's lab focuses on improving treatments for soft-tissue sarcomas, a type of cancer with low survival rates. The research investigates how circular RNAs can affect the immune response to a specific cancer drug called Abemaciclib. By understanding these interactions, the lab aims to enhance the drug's effectiveness and improve outcomes for patients.
soft-tissue sarcomascircular RNAsAbemaciclibtumor microenvironmentimmune responses
Research Aims
3AIM 01Investigate how the circular RNA circCsnk1g3 limits immune responses triggered by Abemaciclib.
AIM 02Evaluate if silencing circCsnk1g3 can boost the anti-tumor effects of Abemaciclib.
AIM 03Assess the role of circCdyl in modulating inflammatory responses in tumor-associated macrophages.
Skills the Lab Values
RNA sequencingflow cytometryco-immunoprecipitationin vivo experimentsgene expression techniques
Output against the department
Publications77bottom 22% of dept.203rd of 259
this lab
most publishedleast published
Citations2.8kbottom 15% of dept.220th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.