UMCUniversity of Massachusetts Chan Medical School · Biochemistry
Thompson Citrullination Lab
Paul R Thompson · Worcester, Massachusetts
Research Focus
Dr. Paul R. Thompson's lab at the University of Massachusetts Medical School focuses on the study of protein citrullination, a process that can be problematic in diseases like rheumatoid arthritis and cancer. The lab aims to develop innovative chemical tools to better understand how this modification affects cell signaling and explore potential new treatments for these serious health conditions. By identifying how citrullination changes protein activity, they seek to uncover its role in disease progression and find targeted therapies.
protein citrullinationPAD biologyautoimmunitycancertherapeutic targetschemoproteomicsisoenzyme inhibitorssignal transductionproteolytic events
Research Aims
4AIM 01Investigate what proteins are citrullinated in human cells.
AIM 02Determine how citrullination affects protein activity.
AIM 03Explore the impact of citrullination on proteolytic events.
AIM 04Develop isozyme-specific inhibitors of PADs.
Skills the Lab Values
chemoproteomicschemical probe developmentgenetic code expansioncell signaling assaysprotein purificationinhibitor designanimal modelsdata analysis using PythonWestern blotting
Output against the department
Publications263top 27% of dept.108th of 402
this lab
most publishedleast published
Citations16ktop 28% of dept.111th of 402
this lab
most citedleast cited
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