UMCUniversity of Massachusetts Chan Medical School · Genetics
Tai Lab
Phillip Tai · Worcester, Massachusetts
Research Focus
Dr. Phillip Tai's lab at the University of Massachusetts Medical School focuses on improving adeno-associated virus (AAV) gene therapies by studying specific genetic sequences known as inverted terminal repeats (ITRs). They explore how variations in these sequences may impact the effectiveness and safety of gene therapies for genetic diseases. Their research combines advanced sequencing methods and animal models to uncover important insights that could lead to safer and more effective treatments.
AAV gene therapyinverted terminal repeatsgenetic diseasesnext-generation sequencinggene integration
Research Aims
3AIM 01Examine the structure and integrity of inverted terminal repeats in wildtype AAVs.
AIM 02Track the outcomes of vectors with truncated/mutated ITRs in cultured human cells and animal models.
AIM 03Investigate the relationship between ITR mutations and gene integration frequencies in non-human primate tissues.
Skills the Lab Values
cell culturenext-generation sequencing (NGS)animal model experimentationgenomic analysismolecular cloning
Output against the department
Publications74bottom 20% of dept.205th of 259
this lab
most publishedleast published
Citations6.4kbottom 34% of dept.171st of 259
this lab
most citedleast cited
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