University of Pennsylvania · NeuroscienceRNA Modifications and Brain Development Lab
Guo-Li Ming · Philadelphia, Pennsylvania
Research Focus
Guo-Li Ming's lab at the University of Pennsylvania focuses on understanding how RNA modifications affect the brain's development and function. This research looks into the roles of various RNA modifications, particularly in relation to neurological disorders. By employing advanced techniques such as stem cell models, the lab aims to uncover the impact of these modifications on brain physiology and diseases like obesity and microcephaly.
RNA modificationsepitranscriptomicsbrain developmentneurogenesisneurological disordersstem cell modelsm6A signalingbrain organoidssynaptic translation
Research Aims
3AIM 01Investigate the role of m6A RNA modifications in neural stem cell fate specification.
AIM 02Explore the impact of locally translated transcripts at synapses in the mouse hippocampus.
AIM 03Assess the effects of risk genes associated with microcephaly on cortical neurogenesis.
Skills the Lab Values
stem cell cultureRNA sequencinggenome editing2D and 3D brain organoid modelsmolecular biology techniquesadvanced sequencing technologiesimmunohistochemistrydata analysis with Pythonexperimental design
Output against the department
Publications422top 14% of dept.95th of 671
this lab
most publishedleast published
Citations52ktop 6% of dept.43rd of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.