Duke University · Mathematics & StatisticsMultigenic Expression Laboratory
Gregory E Crawford · Durham, North Carolina
Research Focus
Dr. Gregory E. Crawford leads a research lab at Duke University focused on the complex interactions of multiple genes in health and diseases. Their work aims to develop innovative technologies that allow researchers to manipulate the expression of many genes simultaneously, moving beyond the traditional single-gene approach in gene therapy and disease modeling. The lab strives to enhance our understanding of how multigenic factors contribute to various conditions, ultimately paving the way for more effective treatments.
gene regulationmultigenic therapygene expressioncell differentiationchromosomal disordersgene therapyepigenome engineeringbiostatisticshealth and disease modeling
Research Aims
3AIM 01Develop technologies for controlling the expression of multiple genes simultaneously.
AIM 02Restore healthy gene expression in diseases linked to complex genetic changes.
AIM 03Control cell differentiation and states through combinatorial gene perturbations.
Skills the Lab Values
PCRgene expression analysismulti-omic sequencingcell culturegenome engineering techniquesdirected evolutionin vitro experimentationdata modelingbioinformaticsstatistical analysis
Output against the department
Publications298top 37% of dept.49th of 131
this lab
most publishedleast published
Citations55ktop 6% of dept.8th of 131
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.