University of Chicago · GeneticsSYNGAP1 Research and Therapy Group
Xiaochang Zhang · Chicago, Illinois
Research Focus
Dr. Xiaochang Zhang's lab focuses on understanding how alterations in the SYNGAP1 gene contribute to neurodevelopmental disorders like autism. The researchers are investigating ways to correct the genetic malfunction by manipulating RNA splicing processes. By studying laboratory mice and human-derived neurons, they aim to develop innovative strategies that could potentially reverse the effects of genetic mutations associated with intellectual disabilities.
SYNGAP1autismalternative splicingneurodevelopmental disorderssplice-switching oligonucleotidesmouse modelsgene therapyRNA splicing
Research Aims
4AIM 01Investigate the role of SYNGAP1 in synaptic transmission and plasticity.
AIM 02Explore alternative splicing mechanisms that lead to gene regulation issues in autism.
AIM 03Develop methods to rescue haploinsufficiency through genetic and oligonucleotide approaches.
AIM 04Examine the effects of SYNGAP1 modifications in mouse models and induced pluripotent stem cell-derived neurons.
Skills the Lab Values
PCRmouse geneticscell cultureelectrophysiologyRNA sequencingsplicing analysisgenetic engineeringimmunofluorescencebehavioral assays
Output against the department
Publications74bottom 20% of dept.206th of 259
this lab
most publishedleast published
Citations3.4kbottom 18% of dept.213th of 259
this lab
most citedleast cited
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