University of South Carolina-Columbia · BiologyWebb Vascular Lab
R Clinton Webb · Columbia, South Carolina
Research Focus
Dr. R Clinton Webb's lab at the University of South Carolina focuses on understanding how diabetes can lead to erectile dysfunction by looking at the role of specific ion channels in blood vessel constriction. The team studies how reactive oxygen species, particularly superoxide, influence vascular signaling and how a particular protein family (LRRC8) might contribute to this process. By uncovering these mechanisms, the lab aims to identify new treatment strategies for erectile dysfunction associated with diabetes, addressing a significant health challenge.
erectile dysfunctiondiabetesion channelsvascular signalingreactive oxygen species
Research Aims
3AIM 01Investigate the role of Nox1 and LRRC8 channels in the production of superoxide in diabetic erectile dysfunction.
AIM 02Examine the effects of LRRC8 knockout on erectile function in diabetic mice.
AIM 03Evaluate potential pharmacological inhibitors of LRRC8 channels as novel treatments for diabetes-related erectile dysfunction.
Skills the Lab Values
cell culturemouse modelspharmacological assaysimmunocytochemistryWestern blotgene knockout techniquesin vivo imagingsignal transduction studies
Output against the department
Publications319top 17% of dept.174th of 1,033
this lab
most publishedleast published
Citations11ktop 35% of dept.365th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.