Stanford University · BiologyRoth Lab
Theodore Lee Roth · Stanford, California
Research Focus
The Roth lab at Stanford University focuses on engineering human cells for therapeutic applications, particularly in cancer treatment. They aim to create new cell states that can enhance the function of primary human T cells using advanced genetic modifications. By leveraging cutting-edge technologies such as CRISPR, the lab explores how to produce new non-evolved human genes to optimize immune responses against tumors.
CRISPRgenetic engineeringT cell therapycancer immunotherapygene synthesiscell state engineeringsynthetic biologysingle-cell sequencingtranscription factors
Research Aims
5AIM 01Develop a platform for combinatorial genetic perturbations in primary human cells.
AIM 02Create new synthetic genes to enhance T cell function.
AIM 03Screen for novel T cell states with therapeutic potential.
AIM 04Analyze the impact of genetic modifications on T cell transcriptomes and chromatin profiles.
AIM 05Explore the stability of synthetic cell states compared to natural human cell types.
Skills the Lab Values
CRISPRcell culturesingle-cell RNA sequencingATAC sequencinggenomic analysisbioinformaticsgenetic manipulationtransfection techniquescomputational biology
Output against the department
Publications85bottom 27% of dept.752nd of 1,033
this lab
most publishedleast published
Citations13ktop 28% of dept.286th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.