University of Nebraska Medical Center · PharmacologyThe Inflammation Initiative
Palsamy Periyasamy · Omaha, Nebraska
Research Focus
Dr. Palsamy Periyasamy's lab at the University Of Nebraska Medical Center focuses on understanding the effects of HIV and methamphetamine on brain inflammation. They study how these substances activate astrocyte-specific inflammasomes, which are important for brain health. The ultimate aim is to identify new therapeutic targets to reduce neuroinflammation in individuals affected by HIV and drug abuse, improving their cognitive function and overall well-being.
HIVneuroinflammationmethamphetamineastrocytesinflammasomePANoptosisneurocognitive disorderstherapeutics
Research Aims
3AIM 01Understand how HIV Tat and methamphetamine activate inflammasomes in astrocytes.
AIM 02Identify the molecular mechanisms involved in neuroinflammation caused by HIV and methamphetamine.
AIM 03Develop novel therapeutic targets for alleviating neuroinflammation in NeuroHIV.
Skills the Lab Values
cell cultureWestern blottingimmunofluorescenceconfocal microscopyRNA sequencinganimal modelsbehavioral assaysDNA methylation analysis
Output against the department
Publications90bottom 21% of dept.361st of 462
this lab
most publishedleast published
Citations5.6kbottom 41% of dept.273rd of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.