Stanford University · BiologyDixon Lab
Scott Dixon · Stanford, California
Research Focus
Scott Dixon's lab at Stanford University focuses on understanding how specific cellular processes can lead to the death of small cell lung cancer (SCLC) cells. By studying the unique metabolism of these cancer cells, particularly how they handle cysteine—a vital amino acid—the lab aims to identify new therapeutic strategies to improve outcomes for SCLC patients. Researchers will explore the differences in cell death mechanisms based on the metabolic state of the cancer cells to develop targeted enzyme therapies.
SCLCcysteine metabolismapoptosisferroptosistumor biologycell death mechanismscancer therapy
Research Aims
3AIM 01Investigate how neuroendocrine cell states influence their response to cysteine deprivation and determine the mechanisms of apoptosis and ferroptosis.
AIM 02Explore the role of Notch and NRF2 signaling pathways in how different SCLC cell states respond to cysteine deprivation.
AIM 03Develop a novel cysteine-degrading enzyme therapy that targets specific cell surface antigens on SCLC cells to induce cell death.
Skills the Lab Values
RNA sequencingmass spectrometrycell cultureapoptosis assaysferroptosis assaysbiochemical pathways analysissignal transduction studiesenzyme therapy developmentanimal models of cancer
Output against the department
Publications181top 37% of dept.378th of 1,033
this lab
most publishedleast published
Citations58ktop 4% of dept.38th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.