University of Arizona · PharmacologyThe Oxidative Heart Lab
Qin M Chen · Tucson, Arizona
Research Focus
Dr. Qin M. Chen's lab at the University of Arizona focuses on understanding how cells respond to oxidative stress, particularly in the context of heart failure. The research investigates the role of specific proteins in activating protective responses that could slow down or prevent heart damage. By exploring RNA methylation and protein translation mechanisms, the lab aims to uncover new strategies for addressing heart failure, a severe and costly health issue.
oxidative stressheart failureprotein translationNrf2mRNA methylationYTHD2cardiomyocytesischemiatranslational regulation
Research Aims
3AIM 01Test if YTHD2 recruits a translation initiation complex during oxidative stress.
AIM 02Investigate how oxidative stress affects methylation patterns on Nrf2 mRNA.
AIM 03Demonstrate the loss of stress-related translation mechanisms during heart failure.
Skills the Lab Values
cell cultureanimal modelsquantitative proteomicsRNA sequencingWestern blotgenetic knockout techniquesbioinformaticsmolecular cloningdata analysis
Output against the department
Publications97bottom 24% of dept.351st of 462
this lab
most publishedleast published
Citations5.2kbottom 38% of dept.286th of 462
this lab
most citedleast cited
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