Massachusetts Institute of Technology · EngineeringThe NeuroDynamics Lab
Manolis Kellis · Cambridge, Massachusetts
Research Focus
Dr. Manolis Kellis leads a research lab at MIT focused on understanding complex neurodegenerative and neuropsychiatric disorders, including Alzheimer's Disease and HIV-associated conditions. The lab uses advanced techniques to dissect the interactions between genetics, immune responses, and cellular changes at a single-cell level. Their work aims to uncover molecular mechanisms that contribute to disease progression and identify potential therapeutic targets.
Alzheimer's DiseaseHIVneuroinflammationsingle-cell analysisimmune responseneuropsychiatrypathogen interactionssubstance use disorderstranscriptional profilingepigenomics
Research Aims
5AIM 01Identify shared genetic mechanisms between HIV, substance use disorders, and Alzheimer’s Disease.
AIM 02Dissect the impact of pathogens on neurodegenerative disease at the single-cell level.
AIM 03Investigate sex-specific differences in Alzheimer's progression using single-cell methods.
AIM 04Develop public resources for sharing single-cell data related to neurodegeneration.
AIM 05Test the functional implications of cholinergic neuron modulation in disease contexts.
Skills the Lab Values
single-cell RNA sequencing (scRNA-seq)mouse modelsepigenomic profiling (scATAC-seq)data analysis using machine learningin vivo experimental characterizationviral vector designcell culture techniquescomputational integration of genomic datapathway analysisbioinformatics
Output against the department
Publications1,142top 2% of dept.5th of 278
this lab
most publishedleast published
Citations126ktop 1% of dept.3rd of 278
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.