RUThe Rockefeller University · Biology
Strickland Neuroinflammation Lab
Sidney Strickland · New York, New York
Research Focus
Dr. Sidney Strickland's lab at Rockefeller University focuses on understanding the mechanisms of Alzheimer's disease (AD), particularly the roles of inflammation and blood clotting. They investigate how interactions between the beta-amyloid peptide and fibrinogen contribute to cognitive decline and vascular dysfunction in AD. The lab aims to develop new therapeutic strategies by targeting these molecular interactions and understanding their impact on brain health.
Alzheimer's Diseasebeta-amyloidfibrinogenneurodegenerationinflammationvascular dysfunctiontherapeuticsblood clottingamyloid peptidesneurotoxicity
Research Aims
5AIM 01Investigate how the plasma contact system contributes to Alzheimer's disease pathology.
AIM 02Determine the effects of beta-amyloid and fibrinogen interactions on neuronal function.
AIM 03Explore the efficacy of contact system inhibitors as potential therapies for Alzheimer's disease.
AIM 04Characterize the role of beta-amyloid protofibrils in activating the plasma contact system.
AIM 05Assess the therapeutic potential of anti-fibrinogen antibodies in Alzheimer's disease.
Skills the Lab Values
PCRanimal modelsmicroscopybiochemical assaysWestern blotprotein purificationcell cultureflow cytometrysurface plasmon resonancecryoelectron microscopy
Output against the department
Publications237top 26% of dept.266th of 1,033
this lab
most publishedleast published
Citations23ktop 16% of dept.170th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.