Washington University in St Louis · NeuroscienceLy Proteomics Lab
Cindy V Ly · Saint Louis, Missouri
Research Focus
Dr. Cindy V Ly's lab at Washington University is focused on understanding amyotrophic lateral sclerosis (ALS), a severe neurodegenerative disease that affects motor neurons. The research aims to identify biomarkers that can help in the diagnosis and treatment of ALS by studying neurofilament proteins, which play a key role in neuron structure and function. The lab combines advanced proteomic techniques with patient biofluids to uncover new insights that could lead to innovative therapeutic strategies.
amyotrophic lateral sclerosisneurodegenerative biomarkersprotein dynamicsproteomicsbiofluid analysisneurofilamentstherapeutic development
Research Aims
5AIM 01Identify neurofilament isoforms and post-translational modifications unique to ALS using proteomic methods.
AIM 02Assess the effectiveness of tofersen treatment by analyzing protein changes in ALS patients' biofluids.
AIM 03Establish robust biomarkers for ALS that can enhance clinical trial efficacy.
AIM 04Explore protein turnover rates in mutant SOD1 proteins compared to wild-type.
AIM 05Develop assays to discriminate between neurofilament isoforms in serum and cerebrospinal fluid.
Skills the Lab Values
proteomicsimmunoassaybiochemical assay developmentstable isotope labeling kinetics (SILK)biofluid collectionmass spectrometrydata analysis using Pythoncell culture techniquespost-translational modification analysis
Output against the department
Publications34bottom 6% of dept.631st of 671
this lab
most publishedleast published
Citations2.7kbottom 17% of dept.557th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.