University of Texas Southwestern Medical Center · Microbiology & ImmunologyD'Orso Virology Lab
Ivan D'Orso · Dallas, Texas
Research Focus
Dr. Ivan D'Orso's lab focuses on understanding how the HIV-1 virus remains hidden in the body and how it can be reactivated. They explore the role of transcription factors and viral enhancers in regulating HIV-1's activation, which could lead to new treatments or cures for HIV infections. By studying cellular models and samples from infected patients, the lab aims to reveal the mechanisms that control HIV's behavior in latent states, contributing to the global effort to end the HIV epidemic.
HIV-1transcription factorslatencyviral enhancersreactivationgene regulationchromatinanti-retroviral therapyfunctional cure
Research Aims
5AIM 01Define the role of transcription factors in initiating HIV-1 reactivation.
AIM 02Explore how viral enhancers facilitate HIV-1 transcription.
AIM 03Investigate the interplay between transcription factors and chromatin accessibility.
AIM 04Understand the mechanisms sustaining HIV-1 latency reactivation.
AIM 05Develop strategies for potential functional cures of HIV-1.
Skills the Lab Values
genetic approachesgenomic techniquesmicroscopycell cultureRNA sequencingCRISPR/Cas technologypolymerase chain reaction (PCR)data analysischromatin accessibility assessments
Output against the department
Publications72bottom 22% of dept.378th of 486
this lab
most publishedleast published
Citations3.4kbottom 25% of dept.364th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.