University of Pittsburgh-Pittsburgh Campus · Microbiology & ImmunologySingh Lab
Harinder Singh · Pittsburgh, Pennsylvania
Research Focus
Dr. Harinder Singh's lab at the University of Pittsburgh focuses on understanding how the immune system, particularly B cells and T follicular helper (TFH) cells, responds to influenza vaccinations in children. The lab uses advanced genomic and immunological techniques to analyze the effectiveness of vaccines and aims to identify the molecular factors that lead to durable antibody responses, potentially improving vaccine strategies.
influenza vaccineB cellsT follicular helper cellsgenomicsimmune responsevaccine effectivenessantibody responsegene regulatory networkschildrenautoimmune diseases
Research Aims
5AIM 01Examine the dynamics of B and TFH cells after flu vaccination in children.
AIM 02Identify genomic factors associated with robust antibody production.
AIM 03Analyze the regulatory networks that control B cell activation and differentiation.
AIM 04Investigate the impact of genetic variation on vaccine responses.
AIM 05Develop tools to predict durable antibody responses based on immune profiling data.
Skills the Lab Values
multi-parameter FACShigh dimensional cytokine profilingsingle cell RNA sequencingcomputational genomicsmachine learningcell culturegenomic profilingbioinformaticsepigeneticsimmunological assays
Output against the department
Publications235top 26% of dept.124th of 486
this lab
most publishedleast published
Citations35ktop 8% of dept.38th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.