West Virginia University · Microbiology & ImmunologyNeuroinflammation and Immune Dynamics Lab
Edwin Chi Keung Wan · Morgantown, West Virginia
Research Focus
Dr. Edwin Chi Keung Wan's lab studies the mechanisms behind multiple sclerosis (MS), a disease that causes inflammation and damage to the nervous system. By focusing on the interactions between specific immune cells in brain tissue, the lab aims to uncover new pathways that could lead to better treatments for MS. The research combines animal models and advanced imaging techniques to explore how particular proteins are involved in the disease process.
multiple sclerosisneuroinflammationSTAT5immune responsemonocytesdendritic cellsTh17 cellsanimal modelsCCL17signaling pathways
Research Aims
3AIM 01Investigate the role of STAT5 tetramers in Th17 cells during EAE.
AIM 02Determine how STAT5 signaling affects monocyte differentiation and interactions at the spinal cord.
AIM 03Explore the role of CCL17 in promoting Th17 cell interactions with dendritic cells.
Skills the Lab Values
PCRcell cultureanimal modelsintravital imagingfluorescence microscopyWestern blotgene expression analysisflow cytometryimmunohistochemistrydata analysis techniques