University of Colorado Boulder · PharmacologyDown Syndrome Research and Therapeutics Lab
Joaquin M. Espinosa · Boulder, Colorado
Research Focus
Dr. Joaquin M. Espinosa's lab at the University of Colorado Denver focuses on understanding and improving the lives of individuals with Down syndrome through innovative research. The lab investigates auditory dysfunction in Down syndrome, aiming to identify the underlying causes of hearing loss and assess therapeutic interventions. Additionally, the team explores Down Syndrome Regression Disorder (DSRD), studying potential treatments and their biological mechanisms.
Down syndromeauditory dysfunctionDown Syndrome Regression Disorderimmune modulationtherapeutic interventionsneurological conditionsco-occurring disordersbiological mechanismsclinical trialsmouse models
Research Aims
5AIM 01Investigate the mechanisms of hearing loss in individuals with Down syndrome.
AIM 02Assess the efficacy of different therapies for Down Syndrome Regression Disorder.
AIM 03Characterize auditory and vestibular function in individuals with Down syndrome.
AIM 04Collect and analyze biospecimens to identify new biomarkers for auditory dysfunction.
AIM 05Examine gene triplication effects on hearing loss using animal models.
Skills the Lab Values
behavioral audiometrytympanometrywideband acoustic immittanceauditory brainstem response testingmouse modelsRNA sequencingclinical trial designbiospecimen collectionneuroinflammatory assaysdeep phenotyping
Output against the department
Publications354top 20% of dept.92nd of 462
this lab
most publishedleast published
Citations13ktop 31% of dept.141st of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.