Boston University · EngineeringWong Lab
Wilson Wong · Boston, Massachusetts
Research Focus
The research lab of Dr. Wilson Wong at Boston University focuses on innovative engineering approaches in synthetic biology, particularly in the development of advanced cellular diagnostic devices and targeted immunotherapies. The lab employs genetic engineering techniques to create more efficient diagnostic circuits and therapeutic cells, addressing challenges in cancer detection and autoimmune diseases like type 1 diabetes. Their work aims to enhance the precision and effectiveness of treatments while ensuring safety and specificity in targeting diseased cells.
cellular diagnosticssynthetic biologyrecombinase circuitsCAR T therapytype 1 diabetesimmune targetingsignal amplificationgene expressionepitope discovery
Research Aims
5AIM 01Develop digital enhancer circuits for signal amplification in cellular diagnostics.
AIM 02Create self-assembled split recombinases for combinatorial logic circuits.
AIM 03Target autoreactive T cells in type 1 diabetes using engineered CAR T cells.
AIM 04Identify peptide-MHC interactions specific to T1D autoreactive TCRs.
AIM 05Evaluate therapeutic efficacy in humanized animal models of type 1 diabetes.
Skills the Lab Values
gene editingcell culture techniquesCAR T cell engineeringrecombinase technologyflow cytometrymolecular cloninganimal modelingdata analysis using Pythonhigh-throughput screening
Output against the department
Publications159bottom 40% of dept.167th of 278
this lab
most publishedleast published
Citations5.1kbottom 41% of dept.165th of 278
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.